細(xì)胞名稱

人急性淋巴細(xì)胞白血病細(xì)胞Nalm6

貨物編碼

BFN60805044

產(chǎn)品規(guī)格

T25培養(yǎng)瓶x1

1.5ml凍存管x2

細(xì)胞數(shù)量

1x10^6

1x10^6

保存溫度

37℃

-198℃

運(yùn)輸方式

常溫保溫運(yùn)輸

干冰運(yùn)輸

安全等級(jí)

1

用途限制

僅供科研           1類

培養(yǎng)體系

DMEM高糖+10%FBS+1%雙抗

培養(yǎng)溫度

37℃

二氧化碳濃度

5%

簡介

人急性淋巴細(xì)胞白血病細(xì)胞Nalm6取自19歲男性供體。該細(xì)胞引種自DSMZ ACC-128

注釋

Part of: Cancer Cell Line Encyclopedia (CCLE) project.

Part of: COSMIC cell lines project.

Part of: LL-100 blood cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.

Doubling time: 25 hours (PubMed=25984343); 19 hours (PubMed=20922763); 40.2 hours (PubMed=8847894); ~36 hours (DSMZ).

Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: Deep RNAseq analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis.

Derived from sampling site: Peripheral blood.

STR信息

Amelogenin        X,Y

CSF1PO        12 (AddexBio; COG; Cosmic-CLP; DSMZ; PubMed=25877200)

12,13 (PubMed=20922763)

13 (RCB; TKG)

D2S1338        17,24

D3S1358        16,17 (COG; PubMed=25877200)

15,16,17 (PubMed=20922763)

D5S818        11 (AddexBio)

10,11,12 (COG; DSMZ; PubMed=25877200)

11,12 (Cosmic-CLP; PubMed=20922763; RCB; TKG)

D7S820        8,12 (AddexBio)

10 (COG)

8,9,10 (Cosmic-CLP; DSMZ; PubMed=25877200)

8,11,12 (PubMed=20922763)

8,11 (RCB; TKG)

D8S1179        11,13,14 (COG; PubMed=25877200)

12,13 (PubMed=20922763)

D13S317        9,11 (AddexBio)

8,9,12 (COG; DSMZ)

9,12 (Cosmic-CLP; PubMed=25877200)

9,12,13 (PubMed=20922763)

9,13 (RCB; TKG)

D16S539        11 (AddexBio)

9,10,11 (COG; DSMZ)

10,11 (Cosmic-CLP; PubMed=20922763; PubMed=25877200; RCB; TKG)

D18S51        12,15 (COG; PubMed=25877200)

11,12,14,15 (PubMed=20922763)

D19S433        13,15 (COG)

12,13,15 (PubMed=20922763)

D21S11        28,29

FGA        21,22 (COG)

22 (PubMed=11416159; PubMed=25877200)

22,23 (PubMed=20922763)

Penta D        8,14

Penta E        11

TH01        8,9 (AddexBio; COG; Cosmic-CLP; DSMZ; PubMed=20922763; RCB; TKG)

8 (PubMed=11416159; PubMed=25877200)

TPOX        8,10

vWA        15,18 (AddexBio)

15,16 (COG; Cosmic-CLP; DSMZ; PubMed=20922763; PubMed=25877200; RCB; TKG)

參考文獻(xiàn)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005

Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.

Characterization of human cancer cell lines by reverse-phase protein arrays.

Cancer Cell 31:225-239(2017)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5

Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747

Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x

Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.

The LL-100 panel: 100 cell lines for blood cancer studies.

Sci. Rep. 9:8218-8218(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023

Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.

Quantitative proteomics of the Cancer Cell Line Encyclopedia.

Cell 180:387-402(2020)